Anti-RAD51AP1 Antibody Picoband®

The RAD51AP1 gene encodes a protein known as RAD51-associated protein 1, which plays a crucial role in homologous recombination, a DNA repair pathway essential for maintaining genomic integrity. RAD51AP1 interacts with RAD51, a key protein involved in homologous recombination, and promotes the assembly of RAD51 nucleoprotein filaments on single-stranded DNA, facilitating the search for homologous sequences and strand exchange. This process is vital for repairing DNA double-strand breaks and stalled replication forks, as well as for meiotic recombination and telomere maintenance. Dysregulation of RAD51AP1 expression or function has been implicated in cancer development and progression, as defects in homologous recombination can lead to genomic instability and oncogenesis. Understanding the molecular mechanisms underlying RAD51AP1-mediated homologous recombination is crucial for deciphering its role in DNA repair and genome maintenance, as well as for developing targeted therapies for cancer and other diseases associated with DNA damage.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.