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Anti-RAMP/ZMYM2 Antibody Picoband®

Boster Bio Anti-RAMP/ZMYM2 Antibody Picoband® catalog # A04648-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Zinc finger MYM-type protein 2 is a protein that in humans is encoded by the ZMYM2 gene. The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL) . Several transcript variants encoding the same protein have been found for this gene.

Synonyms

Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; Neuronal K-Cl cotransporter; SLC12A5; KCC2; KIAA1176

Gene Name

Solute carrier family 12 member 5

UniProt

Q9UBW7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RAMP/ZMYM2 recombinant protein (Position: K573-R1281) .

Clonality

Polyclonal

Tissue Specificity

Brain specific. Detected in neuronal cells.

Applications

ELISA, Flow Cytometry, IF, ICC, WB

Field of Research

Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl- levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04648-1

Product MSDS

https://www.bosterbio.com/msds?sku=A04648-1

Fragment

Rabbit IgG

Applications Notes

6

Other Gene Names

ZMYM2

Subcellular Location

Membrane. Multi-pass membrane protein.

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