Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-INPPL1 Antibody Picoband® (monoclonal, 8C13)

Boster Bio Anti-INPPL1 Antibody Picoband® (monoclonal, 8C13) catalog # M01790. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene. The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.

Synonyms

CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains; CD2AP

Gene Name

CD2 associated protein

UniProt

O15357

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human INPPL1 recombinant protein (Position: R1172-K1258) .

Clonality

Monoclonal

Clone

Clone: 8C13

Tissue Specificity

Widely expressed in fetal and adult tissues.

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Organelle Proteins, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01790

Product MSDS

https://www.bosterbio.com/msds?sku=M01790

Fragment

Mouse IgG2a

Applications Notes

6

Other Gene Names

INPPL1

Subcellular Location

Cytoplasm, cytoskeleton . Cell projection, ruffle . Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity) . During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.

Protein Name

Activating transcription factor 1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human Periostin (POSTN) ELISA Kit
DL-POSTN-Hu 96 Tests

Human Periostin (POSTN) ELISA Kit

Ask
View Details
Tcf25 (BC025071) Mouse Tagged ORF Clone
MG209961 10 µg

Tcf25 (BC025071) Mouse Tagged ORF Clone

Ask
View Details
Human PLEKHA7 shRNA Plasmid
abx965391-01 150 µg

Human PLEKHA7 shRNA Plasmid

Ask
View Details
Human PLEKHA7 shRNA Plasmid
abx965391-02 300 µg

Human PLEKHA7 shRNA Plasmid

Ask
View Details
ATG101 (NM_001098673) Human Tagged ORF Clone Lentiviral Particle
RC221963L4V 200 µL

ATG101 (NM_001098673) Human Tagged ORF Clone Lentiviral Particle

Ask
View Details