Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ABCA4 Antibody Picoband®

Boster Bio Anti-ABCA4 Antibody Picoband® catalog # A01048. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises ly from ABCR-mediated foveal cone degeneration.

Synonyms

Retinal-specific ATP-binding cassette transporter; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Stargardt disease protein; ABCA4; ABCR

Gene Name

Retinal-specific ATP-binding cassette transporter

UniProt

P78363

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ABCA4, different from the related mouse sequence by eight amino acids.

Clonality

Polyclonal

Tissue Specificity

Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.

Applications

WB

Field of Research

Neuroscience, Sensory System, Visual System

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

In the visual cycle, acts as an inward-ed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE) . Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01048

Product MSDS

https://www.bosterbio.com/msds?sku=A01048

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat<br>

Other Gene Names

ABCA4

Subcellular Location

Membrane ; Multi-pass membrane protein . Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.

Protein Name

Retinal-specific ATP-binding cassette transporter

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SHISA4 (NM_198149) Human Tagged ORF Clone
RG210347 10 µg

SHISA4 (NM_198149) Human Tagged ORF Clone

Ask
View Details
Cluster of Differentiation 276 (CD276) Antibody
abx027013-01 80 µL

Cluster of Differentiation 276 (CD276) Antibody

Ask
View Details
Cluster of Differentiation 276 (CD276) Antibody
abx027013-02 400 µL

Cluster of Differentiation 276 (CD276) Antibody

Ask
View Details
Human ADAM33  (A Disintegrin And Metalloprotease 33) ELISA Kit
MBS2540317-01 24 Tests

Human ADAM33  (A Disintegrin And Metalloprotease 33) ELISA Kit

Ask
View Details
Human ADAM33  (A Disintegrin And Metalloprotease 33) ELISA Kit
MBS2540317-02 48 Tests

Human ADAM33  (A Disintegrin And Metalloprotease 33) ELISA Kit

Ask
View Details
Human ADAM33  (A Disintegrin And Metalloprotease 33) ELISA Kit
MBS2540317-03 96 Tests

Human ADAM33  (A Disintegrin And Metalloprotease 33) ELISA Kit

Ask
View Details