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Anti-TRIB2 Antibody Picoband®

Boster Bio Anti-TRIB2 Antibody Picoband® catalog # PB9900. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Tribbles homolog 2 is a protein that in humans is encoded by the TRIB2 gene. This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBP alpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.

Synonyms

Tribbles homolog 2; TRB-2; TRIB2 ; TRB2

Gene Name

Tribbles homolog 2

UniProt

Q92519

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human TRIB2, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in peripheral blood leukocytes. .

Applications

IHC, WB

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Hematopoietic Progenitors, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Serine/Threonine Kinases, Signal Transduction, Stem Cells, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity) . .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PB9900

Product MSDS

https://www.bosterbio.com/msds?sku=PB9900

Fragment

Rabbit IgG

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat <br>Western blot, 0.1-0.5μg/ml, Human<br>

Other Gene Names

TRIB2

Subcellular Location

Cytoplasm . Cytoplasm, cytoskeleton . May associate with the cytoskeleton. .

Protein Name

Tribbles homolog 2

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