Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PD-L1/CD274 Antibody Picoband®

Boster Bio Anti-PD-L1/CD274 Antibody Picoband® catalog # PB9154. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Programmed death-ligand 1 (PD-L1) also known as CD274 or B7-H1 is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy. PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. What’s more, It has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer.

Synonyms

Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; CD274; CD274; B7H1, PDCD1L1, PDCD1LG1, PDL1

Gene Name

Programmed cell death 1 ligand 1

UniProt

Q9NZQ7

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human PD-L1 recombinant protein (Position: E45-T290) . Human PD-L1 shares 69% amino acid (aa) sequence identity with mouse PD-L1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. .

Applications

Flow Cytometry, WB

Field of Research

Autoimmune, Cancer, Cell Type Markers, Immune System Diseases, Immunology, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PB9154

Product MSDS

https://www.bosterbio.com/msds?sku=PB9154

Fragment

Rabbit IgG

Applications Notes

6

Other Gene Names

CD274

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Protein Name

Programmed cell death 1 ligand 1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Anti-Erythropoietin (EPO) (EPO/1367), CF405S conjugate
BNC041367-100 100 µL

Anti-Erythropoietin (EPO) (EPO/1367), CF405S conjugate

Ask
View Details
Rnh1 Adenovirus (Mouse)
40327055 1.0 ml

Rnh1 Adenovirus (Mouse)

Ask
View Details
Mouse CDK18 shRNA Plasmid
abx971957-01 150 µg

Mouse CDK18 shRNA Plasmid

Ask
View Details
Mouse CDK18 shRNA Plasmid
abx971957-02 300 µg

Mouse CDK18 shRNA Plasmid

Ask
View Details
CHAT Recombinant Monoclonal Antibody
A78150-50UL 50 µL

CHAT Recombinant Monoclonal Antibody

Ask
View Details
Recombinant Human MAP3K21 Protein
E30P70257C 50 ug

Recombinant Human MAP3K21 Protein

Ask
View Details