Corydaline

Corydaline ((+) -Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM) . Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities[1][2][3].

Product Specifications

CAS Number

[518-69-4]

Product Name Alternative

(+) -Corydaline; Corydalin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE) ; Enterovirus; Opioid Receptor

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Corydaline.html

Concentration

10mM

Purity

99.70

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@H](C1=CC=C2OC)[C@]3([H])C4=CC(OC)=C(OC)C=C4CCN3CC1=C2OC

Molecular Formula

C22H27NO4

Molecular Weight

369.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Hai-Tao Xiao, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25 (15) :1418-22.|[2]Hui-Qiang Wang, et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19 (11) :1124-1133.|[3]Teresa Kaserer, et al. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10 (1) :13804.