Deltamethrin

Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control[1][2][3][4][5][6].

Product Specifications

CAS Number

[52918-63-5]

Product Name Alternative

Decamethrin

UNSPSC

12352005

Hazard Statement

H301+H331

Target

Apoptosis; Bcl-2 Family; Calcium Channel; Caspase; Endogenous Metabolite; Interleukin Related; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/deltamethrin.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@H]1C(C)(C)[C@H]1/C=C(Br)\Br)O[C@H](C#N)C2=CC=CC(OC3=CC=CC=C3)=C2

Molecular Formula

C22H19Br2NO3

Molecular Weight

505.20

Precautions

H301+H331

References & Citations

[1]Lu Q, et al. Deltamethrin toxicity: A review of oxidative stress and metabolism [J]. Environmental research, 2019, 170: 260-281.|[2]Chi C C, et al. Effect of the pesticide, deltamethrin, on Ca2+ signaling and apoptosis in OC2 human oral cancer cells [J]. Drug and Chemical Toxicology, 2014, 37 (1) : 25-31.|[3]Kumar A, et al. Deltamethrin induced an apoptogenic signalling pathway in murine thymocytes: exploring the molecular mechanism [J]. Journal of Applied Toxicology, 2014, 34 (12) : 1303-1310.|[4]Rehman H, et al. The modulatory effect of deltamethrin on antioxidants in mice [J]. Clinica Chimica Acta, 2006, 369 (1) : 61-65.|[5]Hossain M M, et al. Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain [J]. Life sciences, 2005, 77 (7) : 795-807|[6]Yang X, et al. The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis [J]. Chemosphere, 2022, 300: 134479.