Anti-MLK3 MAP3K11 Antibody

Boster Bio Anti-MLK3 MAP3K11 Antibody catalog # A04412. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Mitogen-activated protein kinase kinase kinase 11;2.7.11.25; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase; MAP3K11

Gene Name

MAP3K11

UniProt

Q16584

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human MLK3. AA range:640-689

Clonality

Polyclonal

Tissue Specificity

Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Molecular Weight

92688 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04412

Product MSDS

https://www.bosterbio.com/msds?sku=A04412

Fragment

IgG

Other Gene Names

Mitogen-activated protein kinase kinase kinase 11

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Protein Name