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Anti-NEK6 Antibody

Boster Bio Anti-NEK6 Antibody catalog # A03740. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Serine/threonine-protein kinase Nek6;2.7.11.1; Never in mitosis A-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512; NEK6;

Gene Name

NEK6

UniProt

Q9HC98

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human protein at AA range: 90-170

Clonality

Polyclonal

Tissue Specificity

Ubiquitous, with highest expression in heart and skeletal muscle.

Applications

WB, ELISA

Purification

NEK6 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848) . Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596) . Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783) . Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501) . Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393) . Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361) .

Molecular Weight

35714 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03740

Product MSDS

https://www.bosterbio.com/msds?sku=A03740

Fragment

IgG

Other Gene Names

Serine/threonine-protein kinase Nek6

Subcellular Location

Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.

Protein Name

Serine/threonine-protein kinase Nek6

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