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Anti-HJURP Antibody

Boster Bio Anti-HJURP Antibody catalog # A03856. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Holliday junction recognition protein;14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9; HJURP; FAKTS, FLEG1

Gene Name

HJURP

UniProt

Q8NCD3

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from human protein at AA range: 80-160

Clonality

Polyclonal

Tissue Specificity

According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.

Applications

WB, ELISA

Purification

HJURP antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

Molecular Weight

83539 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03856

Product MSDS

https://www.bosterbio.com/msds?sku=A03856

Fragment

IgG

Other Gene Names

Holliday junction recognition protein

Subcellular Location

Nucleus, nucleolus. Chromosome, centromere. Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.

Protein Name

Holliday junction recognition protein

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