Anti-Hu CD28 Purified Monoclonal Antibody
Boster Bio Anti-Hu CD28 Purified Monoclonal Antibody (Catalog# M00065) . Tested in Flow Cytometry, IP, WB, IHC-F, ICC application (s) . This antibody reacts with Primate, Human.
Product Specifications
Background
CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
Synonyms
TP44
Gene Name
CD28
UniProt
P10747
Host
Mouse
Reactivity
Primate, Human
Immunogen
DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA. The mouse monoclonal antibody CD28.2 recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
Clonality
Monoclonal
Clone
Clone: CD28.2
Tissue Specificity
Expressed in T-cells and plasma cells, but not in less mature B-cells.
Applications
Flow Cytometry, IP, WB, IHC-F, ICC
Purification
Purified by protein-A affinity chromatography.
Concentration
1 mg/ml
Dilution
Flow cytometry: 1-12 µg/ml
Form
Liquid
Function
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933) . Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037) .
Molecular Weight
25066 MW
Shipping Conditions
Available
Storage Conditions
Store at 2-8°C. Do not freeze.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=M00065
Product MSDS
https://www.bosterbio.com/msds?sku=M00065
Fragment
Mouse IgG1 kappa
Other Gene Names
CD28 molecule
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
T-cell-specific surface glycoprotein CD28
Curated Selection
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