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Anti-Transcription factor HES-5 HES5 Antibody

Boster Bio Anti-Transcription factor HES-5 HES5 Antibody (Catalog # A05384) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1) . The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2) . HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3) .

Synonyms

Hairy and enhancer of split 5, hes family bHLH transcription factor 5, bHLHb38

Gene Name

HES5

UniProt

Q5TA89

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

HES5 antibody is human, mouse and rat reactive. At least two isoforms of HES5 are known to exist; this antibody will detect both isoforms.

Immunogen

HES5 antibody was raised against a 19 amino acid peptide near the amino terminus of human HES5. The immunogen is located within the first 50 amino acids of HES5.

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal heart and brain tumors.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Stem Cells

Purification

HES5 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity) . .

Molecular Weight

18226 MW

Shipping Conditions

Available

Storage Conditions

HES5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A05384

Product MSDS

https://www.bosterbio.com/msds?sku=A05384

Fragment

IgG

Other Gene Names

Hes family bHLH transcription factor

Subcellular Location

Nucleus

Protein Name

Hes family bHLH transcription factor

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