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Anti-SAMSN SAMSN1 Antibody

Boster Bio Anti-SAMSN SAMSN1 Antibody (Catalog # A08977) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

Product Specifications

Background

SAMSN (HACS1) is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains. It encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and malignancies including myeloid leukemia, lymphoma, and myeloma. SAMSN has restricted expression in human tissues. It has been shown to be up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. SAMSN is an immunoinhibitory adaptor that might be a useful target for immune suppression therapy.

Synonyms

SLy2, HACS1, NASH1, SASH2, SH3D6B, SAM domain-containing protein SAMSN-1, Hematopoietic adaptor containing SH3 and SAM domains 1

Gene Name

SAMSN1

UniProt

Q9NSI8

Host

Rabbit

Reactivity

Human

Cross Reactivity

At least two isoforms of SAMSN are known to exist.

Immunogen

Rabbit polyclonal SAMSN antibody was raised against an 18 amino acid peptide near the carboxy terminus of human SAMSN. The immunogen is located within the last 50 amino acids of SAMSN.

Clonality

Polyclonal

Tissue Specificity

Detected in peripheral blood B-cells (at protein level) . Detected in spleen, liver and peripheral blood.

Applications

ELISA, WB, ICC, IF

Field of Research

Immunology

Purification

SAMSN Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro) . Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity) .

Molecular Weight

41708 MW

Shipping Conditions

Available

Storage Conditions

SAMSN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08977

Product MSDS

https://www.bosterbio.com/msds?sku=A08977

Fragment

IgG

Other Gene Names

SAM domain, SH3 domain and nuclear localization signals 1

Subcellular Location

Nucleus

Prediction Reactivity

Mouse

Protein Name

SAM domain, SH3 domain and nuclear localization signals 1

Curated Selection

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