Anti-Transmembrane protein 88 TMEM88 Antibody
Boster Bio Anti-Transmembrane protein 88 TMEM88 Antibody (Catalog # A12951) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.
Synonyms
TMEM88A, Transmembrane protein 88
Gene Name
TMEM88
UniProt
Q6PEY1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
At least two isoforms of TMEM88 are known to exist; this antibody will recognize both isoforms.
Immunogen
TMEM88 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TMEM88. The immunogen is located within amino acids 110 - 160 of TMEM88.
Clonality
Polyclonal
Applications
ELISA, WB, IHC-P, IF
Field of Research
Signal Transduction
Purification
TMEM88 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.
Molecular Weight
17251 MW
Shipping Conditions
Available
Storage Conditions
TMEM88 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A12951
Product MSDS
https://www.bosterbio.com/msds?sku=A12951
Fragment
IgG
Other Gene Names
Transmembrane protein 88
Subcellular Location
Cell membrane
Protein Name
Transmembrane protein 88
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