Anti-TYW4 LCMT2 Antibody
Boster Bio Anti-TYW4 LCMT2 Antibody (Catalog # A14797) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
TYW4 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW4 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.
Synonyms
PPM2, TYW4, KIAA0547, tRNA wybutosine-synthesizing protein 4, Leucine carboxyl methyltransferase 2, tRNA yW-synthesizing protein 4
Gene Name
LCMT2
UniProt
O60294
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
TYW4 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW4 are known to exist; this antibody will detect only the long isoform.
Immunogen
TYW4 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human TYW4. The immunogen is located within the first 50 amino acids of TYW4.
Clonality
Polyclonal
Applications
ELISA, WB, IHC-P, IF
Field of Research
Homeostasis
Purification
TYW4 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity) . May methylate the carboxyl group of leucine residues to form alpha- leucine ester residues. .
Molecular Weight
75602 MW
Shipping Conditions
Available
Storage Conditions
TYW4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A14797
Product MSDS
https://www.bosterbio.com/msds?sku=A14797
Fragment
IgG
Other Gene Names
Leucine carboxyl methyltransferase 2
Protein Name
Leucine carboxyl methyltransferase 2
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