Anti-Axin-2 AXIN2 Antibody

Boster Bio Anti-Axin-2 AXIN2 Antibody (Catalog # A01772) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Synonyms

AXIL, ODCRCS, Axin-2, Axin-like protein, Axil

Gene Name

AXIN2

UniProt

Q9Y2T1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

AXIN2 antibody is predicted to not cross-react with AXIN1. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.

Immunogen

AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. The immunogen is located within amino acids 780 - 830 of AXIN2.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain and lymphoblast.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Cell Cycle

Purification

AXIN2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) . .

Molecular Weight

93558 MW

Shipping Conditions

Available

Storage Conditions

AXIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01772

Product MSDS

https://www.bosterbio.com/msds?sku=A01772

Fragment

IgG

Other Gene Names

Axin 2

Subcellular Location

Cytoplasm.

Prediction Reactivity

Chicken

Protein Name