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Anti-PLAC3 PAPPA2 Antibody

Boster Bio Anti-PLAC3 PAPPA2 Antibody (Catalog # A06838) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP) -5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

Synonyms

PAPPE, PLAC3, PAPP-E, PAPP-A2, Pappalysin-2, Pregnancy-associated plasma protein A2

Gene Name

PAPPA2

UniProt

Q9BXP8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

PLAC3 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human PLAC3. The immunogen is located within amino acids 450 - 500 of PLAC3.

Clonality

Polyclonal

Tissue Specificity

Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.

Applications

ELISA, WB, ICC, IF

Field of Research

Cancer, Cell Cycle

Purification

PLAC3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP) -5 at the '163-Ser-

Molecular Weight

198539 MW

Shipping Conditions

Available

Storage Conditions

PLAC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06838

Product MSDS

https://www.bosterbio.com/msds?sku=A06838

Fragment

IgG

Other Gene Names

Pappalysin 2

Subcellular Location

Secreted .

Protein Name

Pappalysin 2

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