Nitrefazole

Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.

Product Specifications

CAS Number

[21721-92-6]

Product Name Alternative

EMD-15700

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nitrefazole.html

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=NC([N+]([O-])=O)=CN1C2=CC=C([N+]([O-])=O)C=C2

Molecular Formula

C10H8N4O4

Molecular Weight

248.19

References & Citations

[1]Koda LY, Madamba SG, Bloom FE. Hypotensive response of ethanol in rats pretreated with disulfiram or nitrefazole. Life Sci. 1984;35 (16) :1659-1665. |[2]Zorzano A, Herrera E. Differences in the kinetic properties and sensitivity to inhibitors of human placental, erythrocyte, and major hepatic aldehyde dehydrogenase isoenzymes. Biochem Pharmacol. 1990;39 (5) :873-878.