Tubulin polymerization-IN-56

Tubulin polymerization-IN-56 (compound 8l), an indazole derivative, is a potent tubulin polymerization inhibitor through interacting with the colchicine site, resulting in cell cycle arrest and cellular apoptosis. polymerization-IN-56 reduces cell migration and leads to more potent inhibition of tumor growth in vivo[1].

Product Specifications

CAS Number

[2966790-98-5]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-56.html

Purity

99.96

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C2=CC=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)N=C3)=C2)C=N1.Cl

Molecular Formula

C22H22ClN3O3

Molecular Weight

411.88

References & Citations

[1]Ying-Jie Cui, et al. The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors. Eur J Med Chem. 2023 Oct 18:262:115870.