Tubulin polymerization-IN-56
Product Specifications
UNSPSC Description
Tubulin polymerization-IN-56 (compound 8l), an indazole derivative, is a potent tubulin polymerization inhibitor through interacting with the colchicine site, resulting in cell cycle arrest and cellular apoptosis. polymerization-IN-56 reduces cell migration and leads to more potent inhibition of tumor growth in vivo[1].
Target Antigen
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-56.html
Solubility
DMSO : 40 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C2=CC=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)N=C3)=C2)C=N1.Cl
Molecular Weight
411.88
References & Citations
[1]Ying-Jie Cui, et al. The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors. Eur J Med Chem. 2023 Oct 18:262:115870.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155362/Tubulin-polymerization-IN-56-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155362/Tubulin-polymerization-IN-56-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2966790-98-5
Available Sizes
Curated Selection
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