Ezetimibe phenoxy glucuronide

Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

Product Specifications

CAS Number

[190448-57-8]

Product Name Alternative

Ezetimibe glucuronide; Ezetimibe β-D-glucuronide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ezetimibe-phenoxy-glucuronide.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=CC=C(F)C=C5)C3=O)C=C2

Molecular Formula

C30H29F2NO9

Molecular Weight

585.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4 (7) :908-11.|[2]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.