(S,R,S)-AHPC
Product Specifications
Product Name Alternative
VH032-NH2; VHL ligand 1
UNSPSC Description
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].
Target Antigen
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-18.html
Purity
99.13
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 23.81 mg/mL (ultrasonic;adjust pH to 7 with HCl)
Smiles
O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2
Molecular Weight
430.56
References & Citations
[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125845/S-R-S-AHPC-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125845/S-R-S-AHPC-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1448297-52-6
Available Sizes
Curated Selection
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