(S, R, S) -AHPC

(S, R, S) -AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S, R, S) -AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475) . GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

Product Specifications

CAS Number

[1448297-52-6]

Product Name Alternative

VH032-NH2; VHL ligand 1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-18.html

Purity

99.13

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 23.81 mg/mL (ultrasonic; adjust pH to 7 with HCl)

Smiles

O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2

Molecular Formula

C22H30N4O3S

Molecular Weight

430.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.