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Elacridar

Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer[1][2].

Product Specifications

CAS Number

[143664-11-3]

Product Name Alternative

GF120918; GW0918; GG918; GW120918

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

BCRP; P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/elacridar.html

Purity

99.66

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=CC(C(NC(C=C3)=CC=C3CCN4CC(C=C(C(OC)=C5)OC)=C5CC4)=O)=C2NC6=C1C=CC=C6OC

Molecular Formula

C34H33N3O5

Molecular Weight

563.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Sane R, et al. Brain distribution and bioavailability of elacridar after different routes of administration in the mouse. Drug Metab Dispos. 2012 Aug;40 (8) :1612-9.|[2]Sato H, et al. Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells. Eur J Pharmacol. 2015 Jan 5;746:258-66.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Citation 01

Antiviral Res. 2021 Sep:193:105124.|Arch Toxicol. 2025 Jun 7.|Biomed Pharmacother. 2020 Sep;129:110506.|Biomed Res Int. 2020 Nov 29;2020:8878158.|Cancer Lett. 2024 Nov 25:217355.|Cell Death Dis. 2021 Jul 27;12 (8) :742.|Cell Death Dis. 2019 May 24;10 (6) :400. |Cell Metab. 2024 Mar 5;36 (3) :498-510.e11.|Cell Rep. 2020 Jun 23;31 (12) :107782.|Chem Res Toxicol. 2025 Aug 12.|Clin Cancer Res. 2018 Jan 15;24 (2) :383-394.|EJNMMI Res. 2015 Mar 17:5:11.|Eur J Med Chem. 2023 Nov 15:260:115721.|Eur J Pharm Sci. 2025 Sep 1:212:107194.|Hong Kong Polytechnic University. 2022 Oct.|Int J Biol Macromol. 2024 Feb 21;264 (Pt 1) :130377.|Int J Mol Sci. 2019 Mar 5;20 (5) . pii: E1125. |J Agric Food Chem. 2019 Feb 27;67 (8) :2350-2360.|J Agric Food Chem. 2022 Feb 16;70 (6) :1923-1933.|J Biol Chem. 2022 Sep;298 (9) :102353.|J Drug Target. 2016;24 (5) :441-9.|Molecules. 2019 Apr 27;24 (9) :1661.|Preprints. 2024 Jun 19.|Sci Adv. 2023 Oct 20;9 (42) :eabp9530.|Sci Rep. 2021 Jul 22;11 (1) :14948.|Crit Rev Anal Chem. 2022;52 (7) :1557-1571.|Food Chem Toxicol. 2021 Sep:155:112381.|J Mater Chem B. 2018 Dec 7;6 (45) :7521-7529.|Mol Psychiatry. 2023 Sep;28 (9) :3930-3942.|Xenobiotica. 2024 Aug 10:1-15.

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