BCL2 Monoclonal Antibody

Product Specifications

Background

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) .

Abbreviation

Bcl-2

UniProt

P10415

Host

Mouse

Reactivity

Human

Immunogen

Synthetic Peptide

Target

Apoptosis regulator Bcl 2; Apoptosis regulator Bcl-2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; Bcl-2; Bcl2; BCL2; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma; B-cell;2; Oncogene B-cell leukemia 2; PPP1R50; Protein phosphatase 1; regulatory subunit 50

Clonality

Monoclonal

Clone

Clone:1B3

Conjugation

Unconjugated

Applications

Field of Research

Cancer; Cell Biology; Metabolism; Signal Transduction

Purification

Protein A purification

Concentration

1 mg/mL

Dilution

WB 1:1000-2000

Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

26kDa

Observed Molecular Weight

26kDa

Citation 01

https://www.sciencedirect.com/science/article/pii/S0753332220302663

Citation 02

https://link.springer.com/article/10.1007/s11356-023-25636-y

Citation 03

https://europepmc.org/article/pmc/pmc9204490?javascript_support=no

Citation 04

https://www.sciencedirect.com/science/article/pii/S0753332220310763

Citation 05

https://www.nature.com/articles/s41598-019-50679-y

Citation 06

https://www.frontiersin.org/articles/10.3389/fphys.2019.00132/full?report=reader

Citation 07

https://link.springer.com/article/10.1186/s12917-021-02951-5

Isotype

IgG

Available Sizes

Curated Selection

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