SC75741

SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65[1]. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins[2].

Product Specifications

CAS Number

[913822-46-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Influenza Virus; NF-κB

Type

Reference compound

Related Pathways

Anti-infection; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/sc75741.html

Purity

99.51

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC(C=CC(C(C2=CC=CC=C2)=O)=C3)=C3N1)C4=CSC(C(CC5)CCN5C6=NC=NC7=C6SC=C7)=N4

Molecular Formula

C29H23N7O2S2

Molecular Weight

565.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Haasbach E, et al. The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res. 2013 Sep;99 (3) :336-44.|[2]Ehrhardt C, et al. The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance. Cell Microbiol. 2013 Jul;15 (7) :1198-211.