CDC123 Polyclonal Antibody
Product Specifications
Background
The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
Abbreviation
CDC123
UniProt
O75794
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human CDC123
Target
C10orf7; CD123; CDC123; Cell division cycle 123; Cell division cycle 123 homolog; Cell division cycle protein 123 homolog; D123; HT 1080; HT-1080; Protein D123; PZ32
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology
Purification
Antigen affinity purification
Concentration
0.9 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
39 kDa
Observed Molecular Weight
Refer to figures
Isotype
IgG
Available Sizes
Curated Selection
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