DSP Polyclonal Antibody
Product Specifications
Background
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Abbreviation
DSP
UniProt
P15924
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human DSP
Target
250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; Desmoplakin (DPI DPII) ; Desmoplakin; Desmoplakin I; Desmoplakin II; DESP; DP; DP I; DP II; DPI; DPII; DSP; KPPS2; PPKS 2; PPKS2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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