Cephalothin

Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[153-61-7]

Product Name Alternative

Cephalotin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cephalothin.html

Purity

99.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](NC(CC3=CC=CS3)=O)C1=O)O

Molecular Formula

C16H16N2O6S2

Molecular Weight

396.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Morandi S, et al. Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors. Bioorg Med Chem. 2008 Feb 1;16 (3) :1195-205. Epub 2007 Nov 7.|[2]Desiderio JV, et al. Intraphagocytic killing of Salmonella typhimurium by liposome-encapsulated cephalothin. J Infect Dis. 1983 Sep;148 (3) :563-70.|[3]Mobashery S, et al. Reactions of Escherichia coli TEM beta-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters. J Biol Chem. 1986 Jun 15;261 (17) :7879-87.|[4]Cazenave J-P, et al. Effects of cephalothin and penicillin G on platelet function in vitro. Br J Haematol. 1977 Jan;35 (1) :135-52.|[5]Miraglia GJ, et al. Comparison of the chemotherapeutic and pharmacodynamic activities of cephradine, cephalothin, and cephaloridine in mice. Antimicrob Agents Chemother. 1973 Feb;3 (2) :270-3. |[6]Dellinger P, et al. Protective effect of cephalothin against gentamicin-induced nephrotoxicity in rats. Antimicrobial Agents and Chemotherapy, 1976, 9 (1) : 172-178.|[7]Goering RV, et al. Comparison of BL-S786 with cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. J Antibiot (Tokyo) . 1978 Apr;31 (4) :363-72.