Phaseic acid

Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC50 of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect[1][2].

Product Specifications

CAS Number

[24394-14-7]

UNSPSC

12352005

Target

IGluR; Phytohormone

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phaseic-acid.html

Purity

98.76

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C(C)\C=C\[C@]1(O)[C@]2(C)CC(C[C@@]1(C)OC2)=O

Molecular Formula

C15H20O5

Molecular Weight

280.32

References & Citations

[1]Pedro L Rodriguez, et al. Abscisic Acid Catabolism Generates Phaseic Acid, a Molecule Able to Activate a Subset of ABA Receptors. Mol Plant. 2016 Nov 7;9 (11) :1448-1450.|[2]Hou ST, et al., Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain. J Biol Chem. 2016 Dec 30;291 (53) :27007-27022.|[3]Sharkey TD, et al., Effects of phaseic Acid and dihydrophaseic Acid on stomata and the photosynthetic apparatus. Plant Physiol. 1980 Feb;65 (2) :291-7.