Ritolukast
Ritolukast (Wy-48252) is an orally active aerosol leukotriene (LTD4/E4) receptor antagonist. Ritolukast can be used to inhibit the bronchoconstriction caused by aerosol LTD4 in guinea pigs, with an ID50 of 0.5mg/kg[1].
Product Specifications
CAS Number
[111974-60-8]
Product Name Alternative
Wy-48252
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ritolukast.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(NC1=CC(OCC2=NC3=C(C=C2)C=CC=C3)=CC=C1)(C(F)(F)F)=O
Molecular Formula
C17H13F3N2O3S
Molecular Weight
382.36
References & Citations
[1]Hand JM, et al. Prevention and reversal of aerosol LTD4-induced changes in guinea pig pulmonary mechanics by Wy-48252, an orally active LTD4/E4 receptor antagonist. Int Arch Allergy Appl Immunol. 1989;89 (1) :78-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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