Pifithrin-μ

Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.

Product Specifications

CAS Number

[64984-31-2]

Product Name Alternative

PFTμ; 2-Phenylethynesulfonamide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; HSP; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Pifithrin-_mu_.html

Concentration

10mM

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C#CC1=CC=CC=C1)(N)=O

Molecular Formula

C8H7NO2S

Molecular Weight

181.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2 (9) :474-9. Epub 2006 Jul 23.|[2]Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37 (1) :313-322.|[3]Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock. 2018 Feb;49 (2) :229-234.