ALLM

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI) [1][2].

Product Specifications

CAS Number

[110115-07-6]

Product Name Alternative

Calpain inhibitor II

UNSPSC

12352211

Target

Cathepsin; Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/allm.html

Purity

98.60

Solubility

DMSO : ≥ 20 mg/mL

Smiles

CSCC[C@@H](C=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O

Molecular Formula

C19H35N3O4S

Molecular Weight

401.56

References & Citations

[1]Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18 (2) :272-9.|[2]Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22 (3) :398-406.