JNJ0966
JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM.
Product Specifications
CAS Number
[315705-75-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/JNJ0966.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CSC(NC3=C(OC)C=CC=C3)=N2)SC(NC(C)=O)=N1
Molecular Formula
C16H16N4O2S2
Molecular Weight
360.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292 (43) :17963-17974.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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