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JNJ0966

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM.

Product Specifications

CAS Number

[315705-75-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/JNJ0966.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C2=CSC(NC3=C(OC)C=CC=C3)=N2)SC(NC(C)=O)=N1

Molecular Formula

C16H16N4O2S2

Molecular Weight

360.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292 (43) :17963-17974.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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