Vanicoside A

Vanicoside A is a phenylpropanoid glycoside. Vanicoside A can be isolated from Polygonum pensylvanicum. Vanicoside A inhibits protein kinase C (PKC), induces substantial ROS production. Vanicoside A exhibits anticancer activity against melanoma[1][2][3].

Product Specifications

CAS Number

[155179-22-9]

UNSPSC

12352005

Target

PKC; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vanicoside-a.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(OC)C=C(/C=C/C(OC[C@H]2O[C@@H]([C@@H]([C@H]([C@@H]2O)O)OC(C)=O)O[C@@]3(O[C@@H]([C@H]([C@@H]3OC(/C=C/C4=CC=C(C=C4)O)=O)O)COC(/C=C/C5=CC=C(C=C5)O)=O)COC(/C=C/C6=CC=C(C=C6)O)=O)=O)C=C1

Molecular Formula

C51H50O21

Molecular Weight

998.93

References & Citations

[1]Zimmermann ML, Sneden AT. Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum. J Nat Prod. 1994 Feb;57 (2) :236-42.|[2]Nawrot-Hadzik I, et al. Cytotoxic Effect of Vanicosides A and B from Reynoutria sachalinensis Against Melanotic and Amelanotic Melanoma Cell Lines and in silico Evaluation for Inhibition of BRAFV600E and MEK1. Int J Mol Sci. 2020 Jun 29;21 (13) :4611.|[3]Nawrot-Hadzik I, et al. The combination of pro-oxidative acting vanicosides and GLUT1 inhibitor (WZB117) exerts a synergistic cytotoxic effect against melanoma cells. Fitoterapia. 2023 Dec;171:105702.