STL1267
STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1].
Product Specifications
CAS Number
[1429024-58-7]
UNSPSC
12352005
Target
REV-ERB
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/stl1267.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=NN=C2C=CC(OC3=C(C4=CC=CC=C4)C=CC=C3)=NN12
Molecular Formula
C17H11ClN4O
Molecular Weight
322.75
References & Citations
[1]Murray MH, et al. Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun. 2022 Nov 21;13 (1) :7131.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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