Thr101

Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI) .PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) [1].

Product Specifications

CAS Number

[727664-79-1]

UNSPSC

12352005

Target

Glucose-6-Phosphate Isomerase (GPI) ; Phosphomannose Isomerase (PMI)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/thr101.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1N(SC2=CC(F)=CC=C12)C3=CC=CC=C3C

Molecular Formula

C14H10FNOS

Molecular Weight

259.30

References & Citations

[1]Dahl R, et al. Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem. 2011 May 26;54 (10) :3661-8.