Thr101
Product Specifications
UNSPSC Description
Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia)[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/thr101.html
Purity
99.36
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C1N(SC2=CC(F)=CC=C12)C3=CC=CC=C3C
Molecular Weight
259.30
References & Citations
[1]Dahl R, et al. Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem. 2011 May 26;54(10):3661-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124890/Thr101-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124890/Thr101-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
727664-79-1
Available Sizes
Curated Selection
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