GDC-3280
GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673) 's phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects[1].
Product Specifications
CAS Number
[1590403-33-0]
Product Name Alternative
AK3287; AKEX0011
UNSPSC
12352005
Target
ASK1; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ak3287.html
Purity
98.82
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(C3=CN(C)N=C3)=CN1C4=CC=C(C=C4)OC(F)(F)F)N(C)C=N2
Molecular Formula
C18H14F3N5O2
Molecular Weight
389.33
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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