P-nitro-Pifithrin-α

P-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease[1][2][3].

Product Specifications

CAS Number

[389850-21-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Caspase; MDM-2/p53; TGF-β Receptor

Type

Reference compound

Related Pathways

Apoptosis; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/p-nitro-pifithrin-α.html

Purity

97.0

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

N=C1SC2=C(CCCC2)N1CC(C3=CC=C([N+]([O-])=O)C=C3)=O.[H]Br

Molecular Formula

C15H16BrN3O3S

Molecular Weight

398.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am J Nephrol. 2013;37 (2) :97-103.|[2]Zhang F, et al. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Res. 2016 Oct 14;44 (18) :8610-8620.|[3]Derdak Z, et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J Hepatol. 2013 Apr;58 (4) :785-91.