Methyldopate

Methyldopate is an ethyl ester proagent of α-Methyldopa (α-MD; HY-B0225) . Methyldopa (L- (-) -α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors) . Methyldopate has the potential for severe hypertension research [1].

Product Specifications

CAS Number

[6014-30-8]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/methyldopate.html

Purity

98.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCOC([C@@](C)(N)CC1=CC(O)=C(C=C1)O)=O

Molecular Formula

C12H17NO4

Molecular Weight

239.27

Precautions

H302, H312, H332

References & Citations

[1]Hoskins JA, et al. Determination of alpha-methyldopa and methyldopate in human breast milk and plasma by ion-exchange chromatography using electrochemical detection. J Chromatogr. 1982 Jun 11;230 (1) :162-7. |[2]P D Walson, et al. Metabolic disposition and cardiovascular effects of methyldopate in unanesthetized rhesus monkeys. J Pharmacol Exp Ther. 1975 Oct;195 (1) :151-8.