AR 231453

AR 231453 is a potent, specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s[1][2].

Product Specifications

CAS Number

[733750-99-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GPR119

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/AR-231453.html

Concentration

10mM

Purity

99.58

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(C)C1=NOC(C2CCN(C3=NC=NC(NC4=CC=C(S(=O)(C)=O)C=C4F)=C3[N+]([O-])=O)CC2)=N1

Molecular Formula

C21H24FN7O5S

Molecular Weight

505.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148 (6) :2601-9.|[2]J Gao, et al. Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist. Transplant Proc. 2011 Nov;43 (9) :3217-20.