CGP37157
CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria, with an IC50 of 0.8 μM.
Product Specifications
CAS Number
[75450-34-9]
UNSPSC
12352005
Hazard Statement
H302, H400
Target
Na+/Ca2+ Exchanger
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CGP37157.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3Cl)SC1
Molecular Formula
C15H11Cl2NOS
Molecular Weight
324.22
Precautions
H302, H400
References & Citations
[1]Chiesi M, et al. Structural dependency of the inhibitory action of benzodiazepines and related compounds on the mitochondrial Na+-Ca2+ exchanger. Biochem Pharmacol. 1988 Nov 15;37 (22) :4399-403.|[2]Ruiz A, et al. CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels. Cell Death Dis. 2014 Apr 10;5:e1156.|[3]Scherzed A, et al. Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro. Mol Med Rep. 2015 Sep;12 (3) :4455-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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