MIPS521

MIPS521 is a positive allosteric modulator of adenosine A1 receptor (A1AR) . MIPS521 also has a lower A1R allosteric affinity (pKB=4.95; KB=11 μM) . MIPS521 exhibits pain-relieving effects in vivo through modulation of the increased levels of endogenous adenosine[1][2].

Product Specifications

CAS Number

[1146188-19-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mips521.html

Purity

98.21

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(N)SC=C1C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC=C(C=C3)Cl

Molecular Formula

C19H10ClF6NOS

Molecular Weight

449.80

Precautions

H302, H315, H319

References & Citations

[1]Aurelio L, et, al. Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J Med Chem. 2009 Jul 23;52 (14) :4543-7. |[2]Draper-Joyce CJ, et, al. Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature. 2021 Sep;597 (7877) :571-576.