Anti-Sperm-associated antigen 8 SPAG8 Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity) . Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity) . Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270) . May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252) .