Anti-Actin-related protein 2 ACTR2 Antibody
Boster Bio Anti-Actin-related protein 2 ACTR2 Antibody catalog # A03898. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Actin-related protein 2; Actin-like protein 2; ACTR2; ARP2;
Gene Name
ACTR2
UniProt
P61160
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human Arp2 (NP_005713.1) .
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076) . Seems to contact the pointed end of the daughter actin filament (PubMed:9000076) . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947) . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double- strand breaks (DSBs) (PubMed:29925947) .
Molecular Weight
44761 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A03898
Product MSDS
https://www.bosterbio.com/msds?sku=A03898
Other Gene Names
Actin-related protein 2
Subcellular Location
Cytoplasm, cytoskeleton
Protein Name
Actin-related protein 2
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