Anti-SMRTe (K535) NCOR2 Antibody

Nuclear receptor corepressor 2 ; N-CoR2 ; CTG repeat protein 26; SMAP270; Silencing mediator of retinoic acid and thyroid hormone receptor ; SMRT ; T3 receptor-associating factor; TRAC; Thyroid-, retinoic-acid-receptor-associated corepressor; NCOR2

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Transcriptional corepressor (PubMed:20812024) . Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024) .