Anti-IL6ST (phospho-S782) Antibody

Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD130; IL6ST;

Found in all the tissues and cell lines examined (PubMed:2261637) . Expression not restricted to IL6 responsive cells (PubMed:2261637) . Expressed in blood serum (at protein level) (PubMed:24629561) .

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637) . That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003) . Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity) . Has a role in embryonic development (By similarity) . Does not bind IL6 (PubMed:2261637) . Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity) . Required for expression of TRPA1 in nociceptive neurons (By similarity) . Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity) . Required for normal trabecular bone mass and cortical bone composition (By similarity) .