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Anti-AIM2 (A78) Antibody

Boster Bio Anti-AIM2 (A78) Antibody catalog # A00443. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2;

Gene Name

AIM2

UniProt

O14862

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 51-100 of Human AIM2.

Clonality

Polyclonal

Tissue Specificity

Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

IHC: 1:50-1:200

Form

Liquid

Function

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity) . Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Molecular Weight

38954 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00443

Product MSDS

https://www.bosterbio.com/msds?sku=A00443

Other Gene Names

Interferon-inducible protein AIM2

Subcellular Location

Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.

Protein Name

Interferon-inducible protein AIM2

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